“Compassionate Use” and Other Means of Accessing Unproven and Unapproved Treatments Could Impact Long-Term Medical Benefits

Patients facing death or irreversible disease progression – most of whom have exhausted all approved treatment options – sometimes seek access to unapproved and unproven interventions. This type of access, often referred to as “compassionate use,” is  unregulated by federal authorities, subject to corporate pharmaceutical policies that change mid-stream, and could potentially adversely affect  clinical care in the future, according to preliminary studies conducted by researchers and bioethicists at NYU Langone Medical Center Read more...


Scientists Identify the Master Regulator of Cells’ Heat Shock Response, Pointing to New Potential Targets for Neurodegenerative Diseases and Cancer

Heat shock proteins protect the molecules in all human and animal cells with factors that regulate their production and work as thermostats. In new research published in the journal eLife, scientists at NYULMC and elsewhere report for the first time that a protein called translation elongation factor eEF1A1 orchestrates the entire process of the heat shock response. Evgeny Nudler, PhD, the study’s senior investigator, says his team’s latest research shows that eEF1A1 activates transcription by recruiting a key transcription factor to heat shock genes. Read more…