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Featured Faculty: Evgeny A. Nudler, PhD
Julie Wilson Anderson Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology
Evgeny Nudler, PhD, Named Howard Hughes Medical Institute Investigator
Evgeny A. Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology, was recently appointed to the 2013 class of Howard Hughes Medical Institute (HHMI). The appointment ranks as one of the highest honors that can be bestowed upon a biomedical research scientist. HHMI’s current roster of investigators includes 15 Nobel Laureates and more than 160 members of the National Academy of Sciences. Dr. Nudler was among more than 1,200 applicants and was selected for his work on numerous biochemical frontiers, including the role of bacterial gases in antibiotic resistance and the interplay between RNA transcription and the cellular response to stress.
Most recently, Dr. Nudler and his colleagues have discovered how the roundworm exploits bacteria within its gut to harness the life-extending benefits of nitric oxide, a gas implicated in a wide range of physiological functions from blood pressure to immune response in mammals. This finding could help unravel the mysteries of human longevity, as our cells may employ a similar biochemical mechanism.
Dr. Nudler has found that bacteria cells also exploit nitric oxide for their own purposes. In a discovery that sheds light on antibacterial resistance, his team has revealed how the dangerous bacterial species Staphylococcus aureus and Bacillus anthracis manufacture nitric oxide and hydrogen sulfide to guard against oxidative stress and evade many different classes of antibiotics.
Among Dr. Nudler’s other scientific contributions, his team was the first to discover the bits of RNA present in all life forms that function as molecular circuits to control gene expression. These so-called "riboswitches” are now promising new targets for synthetic molecular switches and antimicrobial therapies. In addition, his lab has developed a suite of biochemical tools to examine how RNA polymerase, a key enzyme of gene regulation, transcribes RNA from DNA.
Dr. Nudler received his PhD in biochemistry from the Institute of Molecular Genetics in Moscow, Russia, and completed his postdoctoral training at the Public Health Research Institute.
Source: Office of Communications
Featured Faculty: Evgeny A. Nudler, PhD
Julie Wilson Anderson Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology
Evgeny Nudler, PhD, Named Howard Hughes Medical Institute Investigator
Evgeny A. Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology, was recently appointed to the 2013 class of Howard Hughes Medical Institute (HHMI). The appointment ranks as one of the highest honors that can be bestowed upon a biomedical research scientist. HHMI’s current roster of investigators includes 15 Nobel Laureates and more than 160 members of the National Academy of Sciences. Dr. Nudler was among more than 1,200 applicants and was selected for his work on numerous biochemical frontiers, including the role of bacterial gases in antibiotic resistance and the interplay between RNA transcription and the cellular response to stress.
Most recently, Dr. Nudler and his colleagues have discovered how the roundworm exploits bacteria within its gut to harness the life-extending benefits of nitric oxide, a gas implicated in a wide range of physiological functions from blood pressure to immune response in mammals. This finding could help unravel the mysteries of human longevity, as our cells may employ a similar biochemical mechanism.
Dr. Nudler has found that bacteria cells also exploit nitric oxide for their own purposes. In a discovery that sheds light on antibacterial resistance, his team has revealed how the dangerous bacterial species Staphylococcus aureus and Bacillus anthracis manufacture nitric oxide and hydrogen sulfide to guard against oxidative stress and evade many different classes of antibiotics.
Among Dr. Nudler’s other scientific contributions, his team was the first to discover the bits of RNA present in all life forms that function as molecular circuits to control gene expression. These so-called "riboswitches” are now promising new targets for synthetic molecular switches and antimicrobial therapies. In addition, his lab has developed a suite of biochemical tools to examine how RNA polymerase, a key enzyme of gene regulation, transcribes RNA from DNA.
Dr. Nudler received his PhD in biochemistry from the Institute of Molecular Genetics in Moscow, Russia, and completed his postdoctoral training at the Public Health Research Institute.
Source: Office of Communications
